Article
Discriminating intrinsic and antigen-selected mutational hotspots in immunoglobulin V genes.
Immunology today - 1 Aug 1993
Betz A G, Neuberger M S, Milstein C
Abstract excerpt
Studies of the antibody hypermutation mechanism have revealed that it is not a random process but exhibits characteristic nucleotide substitution preferences. Here, Alexander Betz and colleagues show that these innate nucleotide substitution preferences can be used to examine databases of antigen...
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