Article
Sequence-specific targeting of two bases on both DNA strands by the somatic hypermutation mechanism.
Molecular immunology - 1 Sept 2003
Shapiro Gary S, Ellison Misoo C, Wysocki Lawrence J
Abstract excerpt
Somatic mutations within antibody genes alter the affinity and selectivity of antibody molecules and largely define the quality of the memory B cell repertoire in many vertebrate species. While some evidence supports the idea that there is a strand bias to the hypermutation mechanism, conflicting data suggest that somatic mutations are initially acquired on both strands of DNA. In this study, we utilized a...
Topics
- Animals
- DNA
- Databases, Genetic
- Immunoglobulin Joining Region
- Mice
- Mutagenesis, Site-Directed
- Mutation