Article
Influence of genetic admixture on polymorphisms of drug-metabolizing enzymes: analyses of mutations on NAT2 and C gamma P2E1 genes in a mixed Hispanic population.
Clinical pharmacology and therapeutics - 1 Jun 1998
Martínez C, Agúndez J A, Olivera M, Llerena A, Ramirez R, Hernández M, Benítez J
Abstract excerpt
OBJECTIVES AND STUDY DESIGN: The genetic basis of two polymorphisms of drug- and carcinogen-metabolizing enzymes, NAT2 (arylamine N-acetyltransferase-2) and CYP2E1 (cytochrome P450 2E1), was studied in genomic deoxyribonucleic acid from 137 healthy, unrelated subjects from a mixed Nicaraguan popu...
Topics
- Arylamine N-Acetyltransferase
- Cytochrome P-450 CYP2E1
- Genotype
- Hispanic or Latino
- Humans
- Mutation
- Nicaragua
- Phenotype
- Polymorphism, Genetic