Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Polymorphism p.Val231Ile alters substrate selectivity of drug-metabolizing arylamine N-acetyltransferase 2 (NAT2) isoenzyme of rhesus macaque and human.

Gene - 15 Feb 2014

Tsirka Theodora, Boukouvala Sotiria, Agianian Bogos, Fakis Giannoulis

Abstract excerpt

Arylamine N-acetyltransferases (NATs) are polymorphic enzymes mediating the biotransformation of arylamine/arylhydrazine xenobiotics, including pharmaceuticals and environmental carcinogens. The NAT1 and NAT2 genes, and their many polymorphic variants, have been thoroughly studied in humans by pharmacogeneticists and cancer epidemiologists. However, little is known about the function of NAT homologues in other...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arylamine N-Acetyltransferase
Share to Catalytic Domain

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enzyme Stability

Share to Isoenzymes

Share to Isoleucine

Share to Macaca mulatta

Share to Substrate Specificity

Share to Valine

Source

Identifiers

PMID: 24333853
DOI: 10.1016/j.gene.2013.11.085

Genes

NAT2
NAT1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Polymorphism p.Val231Ile alters substrate selectivity of drug-metabolizing arylamine N-acetyltransferase 2 (NAT2) isoenzyme of rhesus macaque and human.PMID 24333853Read ↗

Functional variability of rhesus macaque (Macaca mulatta) NAT2 gene for drug-metabolising arylamine N-acetyltransferase 2.Semantic proximity Read ↗

Structure/function evaluations of single nucleotide polymorphisms in human N-acetyltransferase 2.Semantic proximity Read ↗

Sequence analysis of NAT2 gene in Brazilians: identification of undescribed single nucleotide polymorphisms and molecular modeling of the N-acetyltransferase 2 protein structure.Semantic proximity Read ↗

Functional genomics of C190T single nucleotide polymorphism in human N-acetyltransferase 2.Semantic proximity Read ↗

Characterization of genetic variation and natural selection at the arylamine N-acetyltransferase genes in global human populations.Semantic proximity Read ↗

Polymorphism of human acetyltransferases.Semantic proximity Read ↗

Deciphering the ancient and complex evolutionary history of human arylamine N-acetyltransferase genes.Semantic proximity Read ↗

Functional characterization of the A411T (L137F) and G364A (D122N) genetic polymorphisms in human N-acetyltransferase 2.Semantic proximity Read ↗

Computational and experimental analyses of mammalian arylamine N-acetyltransferase structure and function.Semantic proximity Read ↗

Functional characterization of human N-acetyltransferase 2 (NAT2) single nucleotide polymorphisms.Semantic proximity Read ↗

Genotyping of the polymorphic N-acetyltransferase (NAT2*) gene locus in two native African populations.Semantic proximity Read ↗

Functional characterization of single-nucleotide polymorphisms and haplotypes of human N-acetyltransferase 2.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.