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Article

Molecular analysis of the arylamine N-acetyltransferase polymorphism in a Spanish population.

Clinical pharmacology and therapeutics - 1 Aug 1994

Agúndez J A, Martínez C, Olivera M, Ledesma M C, Ladero J M, Benítez J

Abstract excerpt

The arylamine N-acetyltransferase (NAT-2) polymorphism causes impaired drug metabolism in about half of the white population. By the combined use of polymerase chain reaction (PCR) and restriction mapping with the endonucleases Fok I and Dde I, we have studied the genetic basis underlying NAT-2 polymorphism in genomic deoxyribonucleic acid from 245 healthy Spaniards. The study of three mutations at the NAT-2 gene...

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Identifiers

PMID: 8062497
DOI: 10.1038/clpt.1994.124

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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