Molecular analysis of the arylamine N-acetyltransferase polymorphism in a Spanish population.

doi:10.1038/clpt.1994.124

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Article

Molecular analysis of the arylamine N-acetyltransferase polymorphism in a Spanish population.

Clinical pharmacology and therapeutics - 1 Aug 1994

Agúndez J A, Martínez C, Olivera M, Ledesma M C, Ladero J M, Benítez J

Abstract excerpt

The arylamine N-acetyltransferase (NAT-2) polymorphism causes impaired drug metabolism in about half of the white population. By the combined use of polymerase chain reaction (PCR) and restriction mapping with the endonucleases Fok I and Dde I, we have studied the genetic basis underlying NAT-2 p...

Topics

Adolescent
Adult
Aged
Aged, 80 and over
Alleles
Arylamine N-Acetyltransferase
Base Sequence
Cohort Studies
DNA
Female
Genotype
Humans
Male
Middle Aged
Molecular Sequence Data
Mutation
Polymerase Chain Reaction
Polymorphism, Genetic

Source

Open in PubMed

Identifiers

PMID: 8062497
DOI: 10.1038/clpt.1994.124

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8062497-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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