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Article

Nicotine metabolism and its association with CYP2A6 genotype among Indigenous people in Alaska who smoke.

Clinical and translational science - 1 Nov 2021

Schaefer Krista R, Avey Jaedon P, Todd Michael R, Beans Julie A, Dillard Denise A, Shireman Laura M, Thornton Timothy A, Tyndale Rachel F, Thummel Kenneth E, Robinson Renee F, Claw Katrina G

Abstract excerpt

Prevalence of smoking is higher in Alaska Native and American Indian (ANAI) populations living in Alaska than the general US population. Genetic factors contribute to smoking and cessation rates. The objective of this study was to compare CYP2A6 genetic variation and CYP2A6 enzyme activity toward nicotine in an ANAI population. ANAI (N = 151) people trying to quit smoking were recruited. DNA samples were...

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PMID: 34520119
DOI: 10.1111/cts.13115
PMCID: PMC8604252

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CYP2A6

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