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Article

CYP2A6 and CYP2B6 genetic variation and its association with nicotine metabolism in South Western Alaska Native people.

Pharmacogenetics and genomics - 1 Jun 2012

Binnington Matthew J, Zhu Andy Z X, Renner Caroline C, Lanier Anne P, Hatsukami Dorothy K, Benowitz Neal L, Tyndale Rachel F

Abstract excerpt

OBJECTIVES: Alaska Native (AN) people have a high prevalence of tobacco use and associated morbidity and mortality when compared with the general USA population. Variations in the CYP2A6 and CYP2B6 genes, encoding enzymes responsible for nicotine metabolic inactivation and procarcinogen activation, have not been characterized in AN and may contribute toward the increased risk. METHODS: AN people (n=400) residing...

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Source

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Identifiers

PMID: 22569203
DOI: 10.1097/FPC.0b013e3283527c1c
PMCID: PMC3349071

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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