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Article

Variation in CYP2A6 and nicotine metabolism among two American Indian tribal groups differing in smoking patterns and risk for tobacco-related cancer.

Pharmacogenetics and genomics - 1 May 2017

Tanner Julie-Anne, Henderson Jeffrey A, Buchwald Dedra, Howard Barbara V, Nez Henderson Patricia, Tyndale Rachel F

Abstract excerpt

OBJECTIVE: The Northern Plains (NP) and Southwest (SW) American Indian populations differ in their smoking patterns and lung cancer incidence. We aimed to compare CYP2A6 genetic variation and CYP2A6 enzyme activity (representative of the rate of nicotine metabolism) between the two tribal populations as these have previously been associated with differences in smoking, quitting, and lung cancer risk. PARTICIPANTS...

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Identifiers

PMID: 28181923
DOI: 10.1097/FPC.0000000000000271
PMCID: PMC5382092

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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