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Article

Linear amplicons as precursors of amplified circles in methotrexate-resistant Leishmania tarentolae.

Nucleic acids research - 15 Jul 1998

Grondin K, Kündig C, Roy G, Ouellette M

Abstract excerpt

Gene amplification is frequently observed in Leishmania cells selected for drug resistance. By gene targeting we have tagged both alleles of the H locus of Leishmania tarentolae with the neomycin and hygromycin phosphotransferase genes ( neo and hyg ). Selection of these recombinant parasites for...

Topics

Alleles
Animals
DNA, Circular
DNA, Protozoan
Drug Resistance
Gene Amplification
Leishmania
Methotrexate
Mutation

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 9649621
DOI: 10.1093/nar/26.14.3372
PMCID: PMC147699

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9649621-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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