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Article

Modulation of gene expression in drug resistant Leishmania is associated with gene amplification, gene deletion and chromosome aneuploidy.

Genome biology - 1 Jan 2008

Ubeda Jean-Michel, Légaré Danielle, Raymond Frédéric, Ouameur Amin Ahmed, Boisvert Sébastien, Rigault Philippe, Corbeil Jacques, Tremblay Michel J, Olivier Martin, Papadopoulou Barbara, Ouellette Marc

Abstract excerpt

BACKGROUND: Drug resistance can be complex, and several mutations responsible for it can co-exist in a resistant cell. Transcriptional profiling is ideally suited for studying complex resistance genotypes and has the potential to lead to novel discoveries. We generated full genome 70-mer oligonucleotide microarrays for all protein coding genes of the human protozoan parasites Leishmania major and Leishmania...

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Identifiers

PMID: 18638379
DOI: 10.1186/gb-2008-9-7-r115
PMCID: PMC2530873

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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