Article
Homologous recombination between direct repeat sequences yields P-glycoprotein containing amplicons in arsenite resistant Leishmania.
Nucleic acids research - 25 Apr 1993
Grondin K, Papadopoulou B, Ouellette M
Abstract excerpt
The protozoan parasite Leishmania often responds to drug pressure by amplifying part of its genome. At least two loci derived from the same 800 kb chromosome were amplified either as extrachromosomal circles or linear fragments after sodium arsenite selection. A 50 kb linear amplicon was detected...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Animals
- Argininosuccinate Synthase
- Arsenic
- Arsenites
- Base Sequence
- Carrier Proteins
- DNA, Circular
- DNA, Protozoan
- Drug Resistance
- Gene Amplification
- Genes, Protozoan
- Leishmania
- Membrane Glycoproteins
- Molecular Sequence Data
- Mutation
- Oxidoreductases
- Polymerase Chain Reaction