Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Homologous recombination between direct repeat sequences yields P-glycoprotein containing amplicons in arsenite resistant Leishmania.

Nucleic acids research - 25 Apr 1993

Grondin K, Papadopoulou B, Ouellette M

Abstract excerpt

The protozoan parasite Leishmania often responds to drug pressure by amplifying part of its genome. At least two loci derived from the same 800 kb chromosome were amplified either as extrachromosomal circles or linear fragments after sodium arsenite selection. A 50 kb linear amplicon was detected in six independent arsenite mutants and revertants grown in absence of arsenite rapidly lost the amplicon and part of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Carrier Proteins
Share to Drug Resistance

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Amplification

Share to Membrane Glycoproteins

Share to Molecular Sequence Data

Share to Mutation

Share to Polymerase Chain Reaction

Source

Open in PubMed Open full text

Identifiers

PMID: 8098523
DOI: 10.1093/nar/21.8.1895
PMCID: PMC309430

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Homologous recombination between direct repeat sequences yields P-glycoprotein containing amplicons in arsenite resistant Leishmania.PMID 8098523Read ↗

Organization of H locus conserved repeats in Leishmania (Viannia) braziliensis correlates with lack of gene amplification and drug resistance.Semantic proximity Read ↗

Linear amplicons as precursors of amplified circles in methotrexate-resistant Leishmania tarentolae.Semantic proximity Read ↗

Frequency of Drug Resistance Gene Amplification in ClinicalLeishmaniaStrainsSemantic proximity Read ↗

Modulation of gene expression in drug resistant Leishmania is associated with gene amplification, gene deletion and chromosome aneuploidy.Semantic proximity Read ↗

Frequent amplification of a short chain dehydrogenase gene as part of circular and linear amplicons in methotrexate resistant Leishmania.Semantic proximity Read ↗

Telomeric gene deletion and intrachromosomal amplification in antimony-resistant Leishmania.Semantic proximity Read ↗

Genetic coping mechanisms observed in Leishmania tropica, from the Middle East region, enhance the survival of the parasite after drug exposure.Semantic proximity Read ↗

Genomic Flexibility Through Extrachromosomal Amplifications: A <i>Leishmania</i> Survival StrategySemantic proximity Read ↗

Gene expression modulation is associated with gene amplification, supernumerary chromosomes and chromosome loss in antimony-resistant Leishmania infantum.Semantic proximity Read ↗

GENE AMPLIFICATION IN LEISHMANIASemantic proximity Read ↗

Two distinct arsenite-resistant variants of Leishmania amazonensis take different routes to achieve resistance as revealed by comparative transcriptomics.Semantic proximity Read ↗

Gene disruption of the P-glycoprotein related gene pgpa of Leishmania tarentolae.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.