Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Frequent amplification of a short chain dehydrogenase gene as part of circular and linear amplicons in methotrexate resistant Leishmania.

Nucleic acids research - 11 Sept 1993

Papadopoulou B, Roy G, Ouellette M

Abstract excerpt

The H locus of Leishmania codes for a short chain dehydrogenase gene (ltdh) that is involved in antifolate resistance. Leishmania tarentolae cells, selected in a step by step fashion for resistance to the antifolate methotrexate (MTX), frequently amplified ltdh in response to drug selection. Both circular and linear extrachromosomal amplicons were generated de novo from the chromosomal H locus and several...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biological Transport
Share to Chromosomes
Share to DNA, Protozoan

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Drug Resistance

Share to Gene Amplification

Share to Gene Rearrangement

Share to Mutation

Share to Oxidoreductases

Source

Open in PubMed Open full text

Identifiers

PMID: 8414986
DOI: 10.1093/nar/21.18.4305
PMCID: PMC310065

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Frequent amplification of a short chain dehydrogenase gene as part of circular and linear amplicons in methotrexate resistant Leishmania.PMID 8414986Read ↗

Changes in folate and pterin metabolism after disruption of the Leishmania H locus short chain dehydrogenase gene.Semantic proximity Read ↗

Linear amplicons as precursors of amplified circles in methotrexate-resistant Leishmania tarentolae.Semantic proximity Read ↗

GENE AMPLIFICATION IN LEISHMANIASemantic proximity Read ↗

Homologous recombination between direct repeat sequences yields P-glycoprotein containing amplicons in arsenite resistant Leishmania.Semantic proximity Read ↗

Modulation of gene expression in drug resistant Leishmania is associated with gene amplification, gene deletion and chromosome aneuploidy.Semantic proximity Read ↗

Role of the locus and of the resistance gene on gene amplification frequency in methotrexate resistant Leishmania tarentolae.Semantic proximity Read ↗

Increased transport of pteridines compensates for mutations in the high affinity folate transporter and contributes to methotrexate resistance in the protozoan parasite Leishmania tarentolae.Semantic proximity Read ↗

Genomic Flexibility Through Extrachromosomal Amplifications: A <i>Leishmania</i> Survival StrategySemantic proximity Read ↗

Organization of H locus conserved repeats in Leishmania (Viannia) braziliensis correlates with lack of gene amplification and drug resistance.Semantic proximity Read ↗

High affinity S-Adenosylmethionine plasma membrane transporter of Leishmania is a member of the folate biopterin transporter (FBT) family.Semantic proximity Read ↗

Gene amplification and point mutations in pyrimidine metabolic genes in 5-fluorouracil resistant Leishmania infantum.Semantic proximity Read ↗

Overexpression of AP endonuclease protects Leishmania major cells against methotrexate induced DNA fragmentation and hydrogen peroxide.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.