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Article

Gene amplification in amphotericin B-resistant Leishmania tarentolae.

Experimental parasitology - 1 Nov 2001

Singh A K, Papadopoulou B, Ouellette M

Abstract excerpt

Two Leishmania tarentolae cells were selected step by step for resistance to the polyene antibiotic amphotericin B, a second-line drug against the parasite Leishmania. One of the mutants was cross-resistant to ketoconazole. DNA amplification was observed in both mutants. The amplicons were extrachromosomal circles and were derived from different chromosomes. In one mutant the circle was unusually stable as it...

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Identifiers

PMID: 11846524
DOI: 10.1006/expr.2001.4663

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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