Article
A population study of mutations and LOH at breast cancer gene loci in tumours from sister pairs: two recurrent mutations seem to account for all BRCA1/BRCA2 linked breast cancer in Iceland.
Journal of medical genetics - 1 Jun 1998
Arason A, Jonasdottir A, Barkardottir R B, Bergthorsson J T, Teare M D, Easton D F, Egilsson V
Abstract excerpt
The majority of breast cancer in high risk families is believed to result from a mutation in either of two genes named BRCA1 and BRCA2. A germline defect in either gene is usually followed by chromosomal deletion of the normal allele in the tumour. In Iceland two recurrent mutations have been ide...
Topics
- Age Factors
- BRCA1 Protein
- BRCA2 Protein
- Breast Neoplasms
- Female
- Gene Deletion
- Genes, BRCA1
- Genetic Carrier Screening
- Genetic Markers
- Humans
- Middle Aged
- Mutation
- Neoplasm Proteins
- Nuclear Family