Article
Population-based study of risk of breast cancer in carriers of BRCA2 mutation.
Lancet (London, England) - 24 Oct 1998
Thorlacius S, Struewing J P, Hartge P, Olafsdottir G H, Sigvaldason H, Tryggvadottir L, Wacholder S, Tulinius H, Eyfjörd J E
Abstract excerpt
BACKGROUND: Estimates of an 80-90% risk of breast cancer for carriers of germline mutations in the BRCA1 and BRCA2 genes are based on studies of families at high risk of breast cancer. Risk estimates for a population are possible if the mutation status of a representative sample of that populatio...
Topics
- Aged
- BRCA2 Protein
- Breast Neoplasms
- Breast Neoplasms, Male
- Female
- Heterozygote
- Humans
- Iceland
- Male
- Middle Aged
- Mutation
- Neoplasm Proteins
- Pedigree
- Population Surveillance
- Prostatic Neoplasms
- Registries
- Risk Factors
- Transcription Factors