Article
A single BRCA2 mutation in male and female breast cancer families from Iceland with varied cancer phenotypes.
Nature genetics - 1 May 1996
Thorlacius S, Olafsdottir G, Tryggvadottir L, Neuhausen S, Jonasson J G, Tavtigian S V, Tulinius H, Ogmundsdottir H M, Eyfjörd J E
Abstract excerpt
The BRCA2 gene on chromosome 13 has been shown to be associated with familial male and female breast cancer. Here we describe a study on BRCA2 in 21 Icelandic families, including 9 with male breast cancer. We have previously reported linkage to the BRCA2 region in an Icelandic male breast cancer...
Topics
- BRCA2 Protein
- Base Composition
- Breast Neoplasms
- Breast Neoplasms, Male
- Chromosomes, Human, Pair 13
- Endometrial Neoplasms
- Exons
- Family
- Female
- Genetic Linkage
- Genetic Markers
- Haplotypes
- Humans
- Iceland
- Male
- Neoplasm Proteins
- Pedigree
- Phenotype