Article
BRCA2 mutations in 154 finnish male breast cancer patients.
Neoplasia (New York, N.Y.) - 1 Jan 2000
Syrjäkoski Kirsi, Kuukasjärvi Tuula, Waltering Kati, Haraldsson Karin, Auvinen Anssi, Borg Ake, Kainu Tommi, Kallioniemi Olli-P, Koivisto Pasi A
Abstract excerpt
The etiology and pathogenesis of male breast cancer (MBC) are poorly known. This is due to the fact that the disease is rare, and large-scale genetic epidemiologic studies have been difficult to carry out. Here, we studied the frequency of eight recurrent Finnish BRCA2 founder mutations in a large cohort of 154 MBC patients (65% diagnosed in Finland from 1967 to 1996). Founder mutations were detected in 10...
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