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Article

Population-based study of changing breast cancer risk in Icelandic BRCA2 mutation carriers, 1920-2000.

Journal of the National Cancer Institute - 18 Jan 2006

Tryggvadottir Laufey, Sigvaldason Helgi, Olafsdottir Gudridur H, Jonasson Jon G, Jonsson Thorvaldur, Tulinius Hrafn, Eyfjörd Jorunn E

Abstract excerpt

BACKGROUND: Mutations in the BRCA genes increase the risk of breast cancer. Valid estimates of the magnitude of the lifetime risk of breast cancer in BRCA gene mutation carriers are needed for genetic counseling. Recent results suggest that penetrance has increased in recent birth cohorts. We examined the cumulative breast cancer incidence and mortality before age 70 over a diagnosis period of 80 years in...

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PMID: 16418514
DOI: 10.1093/jnci/djj012

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BRCA2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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