Article
The effect of a single BRCA2 mutation on cancer in Iceland.
Journal of medical genetics - 1 Jul 2002
Tulinius H, Olafsdottir G H, Sigvaldason H, Arason A, Barkardottir R B, Egilsson V, Ogmundsdottir H M, Tryggvadottir L, Gudlaugsdottir S, Eyfjord J E
Abstract excerpt
OBJECTIVE: To estimate the risk of malignant diseases in families of probands with the same mutation in the BRCA2 gene. DESIGN: A cohort study using record linkage of a breast cancer family resource and the Icelandic Cancer Registry. SETTING: Iceland. SUBJECTS: Families of 995 breast cancer patients, from which 887 were tested for a single founder 999del5 mutation; 90 had the mutation and 797 did not. RESULTS:...
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