Article
A low proportion of BRCA2 mutations in Finnish breast cancer families.
American journal of human genetics - 1 May 1997
Vehmanen P, Friedman L S, Eerola H, Sarantaus L, Pyrhönen S, Ponder B A, Muhonen T, Nevanlinna H
Abstract excerpt
One hundred breast cancer families were identified at the Helsinki University Central Hospital in Finland and were screened for germ-line mutations in the coding regions and splice boundaries of the BRCA2 gene. Eight families (8%) were found to carry five different mutations, all of which are predicted to prematurely truncate the protein product. These BRCA2 families have early-onset breast cancer (mean and...
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