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Article

B-cell superantigens may play a role in B-cell development and selection in the young rabbit appendix.

Cellular immunology - 1 May 1998

Pospisil R, Mage R G

Abstract excerpt

In order to develop protective antibodies against a wide range of potentially infectious pathogens, the young rabbit must diversify a limited initial repertoire by somatic mechanisms (the high copy number primary repertoire). The majority of rabbit B cells produce heavy chain variable regions by rearranging the VHa allotype-encoding VH1 gene. Thus in normal rabbits the majority of serum immunoglobulins bear VHa...

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Identifiers

PMID: 9636687
DOI: 10.1006/cimm.1998.1288

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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B-cell superantigens may play a role in B-cell development and selection in the young rabbit appendix.PMID 9636687Read ↗

Development of the antibody repertoire in rabbit: gut-associated lymphoid tissue, microbes, and selection.Semantic proximity Read ↗

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Characterization of a rabbit germ-line VH gene that is a candidate donor for VH gene conversion in mutant Alicia rabbits.Semantic proximity Read ↗

Diversification of rabbit VH genes by gene-conversion-like and hypermutation mechanisms.Semantic proximity Read ↗

Distinct clonal Ig diversification patterns in young appendix compared to antigen-specific splenic clones.Semantic proximity Read ↗

Preferrential rearrangement in normal rabbits of the 3' VHa allotype gene that is deleted in Alicia mutants; somatic hypermutation/conversion may play a major role in generating the heterogeneity of rabbit heavy chain variable region sequences.Semantic proximity Read ↗

Somatic diversification of immunoglobulin heavy chain VDJ genes: evidence for somatic gene conversion in rabbits.Semantic proximity Read ↗

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Molecular bases of genetic diversity and evolution of the immunoglobulin heavy chain variable region (IGHV) gene locus in leporids.Semantic proximity Read ↗

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