Rabbit IgH sequences in appendix germinal centers: VH diversification by gene conversion-like and hypermutation mechanisms.

doi:10.1016/1074-7613(94)90036-1

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Article

Rabbit IgH sequences in appendix germinal centers: VH diversification by gene conversion-like and hypermutation mechanisms.

Immunity - 1 Nov 1994

Weinstein P D, Anderson A O, Mage R G

Abstract excerpt

Although the rabbit IgH locus contains approximately 100 VH genes, the majority of B cells rearrange VH1. To produce a primary repertoire containing a sufficient number of protective antibodies, rearranged VH1-DH-JH sequences may diversify within rabbit B cells in an organ that functions like a chicken bursa, sheep ileal Peyer's patch, or both. It was suggested many years ago that the rabbit appendix could be a...

Topics

Amino Acid Sequence
Animals
Antibody Diversity
Antibody Formation
Appendix
B-Lymphocytes
Base Sequence
Cloning, Molecular
Gene Conversion
Gene Rearrangement, B-Lymphocyte, Heavy Chain
Genes, Immunoglobulin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lymphoid Tissue

Models, Genetic

Molecular Sequence Data

Mutation

Polymerase Chain Reaction

Rabbits

Sequence Alignment

Source

Open in PubMed

Identifiers

PMID: 7600292
DOI: 10.1016/1074-7613(94)90036-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7600292-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Rabbit IgH sequences in appendix germinal centers: VH diversification by gene conversion-like and hypermutation mechanisms.PMID 7600292Read ↗

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