Article
Preferrential rearrangement in normal rabbits of the 3' VHa allotype gene that is deleted in Alicia mutants; somatic hypermutation/conversion may play a major role in generating the heterogeneity of rabbit heavy chain variable region sequences.
European journal of immunology - 1 Feb 1991
Allegrucci M, Young-Cooper G O, Alexander C B, Newman B A, Mage R G
Abstract excerpt
The rabbit is unique in having well-defined allotypes in the variable region of the heavy chain. Products of the VHa locus, (with alleles a1, a2, and a3), account for the majority of the serum immunoglobulins. A small percentage of the serum immunoglobulins are a-negative. In 1986, Kelus and Weiss described a mutation that depressed the expression of the Ig VH a2 genes in an a1/a2 rabbit. From this animal the...
Topics
- Animals
- B-Lymphocytes
- Blotting, Southern
- Electrophoresis
- Gene Rearrangement, B-Lymphocyte, Heavy Chain
- Heterozygote
- Immunoglobulin Allotypes
- Immunoglobulin Variable Region
- Mutation