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Article

Somatic diversification of immunoglobulin heavy chain VDJ genes: evidence for somatic gene conversion in rabbits.

Cell - 30 Nov 1990

Becker R S, Knight K L

Abstract excerpt

Rabbits preferentially utilize only one of their multiple functional germline immunoglobulin VH genes. This preferential usage of one gene, VH1, raises the question of how rabbits generate antibody diversity. VDJ diversification was analyzed by cloning and sequencing VH1 gene rearrangements. Comparison of these sequences with that of germline VH1 identified clusters of nucleotide changes, including codon...

Read the complete abstract on PubMed

Topics

Animals
Base Sequence
Blotting, Southern
Cloning, Molecular
DNA
Gene Conversion
Gene Rearrangement

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Genes, Immunoglobulin

Genetic Variation

Haplotypes

Homozygote

Immunoglobulin Heavy Chains

Molecular Sequence Data

Polymerase Chain Reaction

Rabbits

Restriction Mapping

Sequence Homology, Nucleic Acid

Spleen

Source

Identifiers

PMID: 2124176
DOI: 10.1016/0092-8674(90)90502-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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