Somatic diversification of immunoglobulin heavy chain VDJ genes: evidence for somatic gene conversion in rabbits.

doi:10.1016/0092-8674(90)90502-6

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Article

Somatic diversification of immunoglobulin heavy chain VDJ genes: evidence for somatic gene conversion in rabbits.

Cell - 30 Nov 1990

Becker R S, Knight K L

Abstract excerpt

Rabbits preferentially utilize only one of their multiple functional germline immunoglobulin VH genes. This preferential usage of one gene, VH1, raises the question of how rabbits generate antibody diversity. VDJ diversification was analyzed by cloning and sequencing VH1 gene rearrangements. Comp...

Topics

Animals
Base Sequence
Blotting, Southern
Cloning, Molecular
DNA
Gene Conversion
Gene Rearrangement
Genes, Immunoglobulin
Genetic Variation
Haplotypes
Homozygote
Immunoglobulin Heavy Chains

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Polymerase Chain Reaction

Rabbits

Restriction Mapping

Sequence Homology, Nucleic Acid

Spleen

Source

Open in PubMed

Identifiers

PMID: 2124176
DOI: 10.1016/0092-8674(90)90502-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2124176-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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