Article
Preferential expansion and survival of B lymphocytes based on VH framework 1 and framework 3 expression: "positive" selection in appendix of normal and VH-mutant rabbits.
Proceedings of the National Academy of Sciences of the United States of America - 18 Jul 1995
Pospisil R, Young-Cooper G O, Mage R G
Abstract excerpt
B cells with a rearranged heavy-chain variable region VHa allotype-encoding VH1 gene segment predominate throughout the life of normal rabbits and appear to be the source of the majority of serum immunoglobulins, which thus bear VHa allotypes. The functional role(s) of these VH framework region (...
Topics
- Animals
- Apoptosis
- Appendix
- B-Lymphocytes
- Cell Cycle
- Cell Survival
- DNA Damage
- Flow Cytometry
- Immunoglobulin Allotypes
- Immunoglobulin Heavy Chains
- Immunoglobulin Variable Region
- Immunohistochemistry
- Lymphocyte Activation
- Mutation
- Rabbits
- Selection, Genetic