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Article

Characterization of a rabbit germ-line VH gene that is a candidate donor for VH gene conversion in mutant Alicia rabbits.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 1995

Chen H T, Alexander C B, Mage R G

Abstract excerpt

Normal rabbits preferentially rearrange the 3'-most VH gene, VH1, to encode Igs with VHa allotypes, which constitute the majority of rabbit serum Igs. A gene conversion-like mechanism is employed to diversify the primary Ab repertoire. In mutant Alicia rabbits that derived from a rabbit with VHa2 allotype, the VH1 gene was deleted. Our previous studies showed that the first functional gene (VH4) or VH4-like genes...

Topics

Amino Acid Sequence
Animals
Antibody Diversity
Base Sequence
DNA, Complementary
Gene Conversion
Gene Rearrangement, B-Lymphocyte, Heavy Chain
Genes, Immunoglobulin
Immunoglobulin Heavy Chains
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Rabbits

Sequence Homology, Amino Acid

Sequence Homology, Nucleic Acid

Source

Identifiers

PMID: 7759874

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7759874-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Characterization of a rabbit germ-line VH gene that is a candidate donor for VH gene conversion in mutant Alicia rabbits.PMID 7759874Read ↗

VH gene expression and regulation in the mutant Alicia rabbit. Rescue of VHa2 allotype expression.Semantic proximity Read ↗

VH mutant rabbits lacking the VH1a2 gene develop a2+ B cells in the appendix by gene conversion-like alteration of a rearranged VH4 gene.Semantic proximity Read ↗

Preferrential rearrangement in normal rabbits of the 3' VHa allotype gene that is deleted in Alicia mutants; somatic hypermutation/conversion may play a major role in generating the heterogeneity of rabbit heavy chain variable region sequences.Semantic proximity Read ↗

Limited number of immunoglobulin VH regions expressed in the mutant rabbit "Alicia".Semantic proximity Read ↗

Molecular basis of the allelic inheritance of rabbit immunoglobulin VH allotypes: implications for the generation of antibody diversity.Semantic proximity Read ↗

B lymphocyte selection and age-related changes in VH gene usage in mutant Alicia rabbits.Semantic proximity Read ↗

Diversification of rabbit VH genes by gene-conversion-like and hypermutation mechanisms.Semantic proximity Read ↗

VDJ genes in VHa2 allotype-suppressed rabbits. Limited germline VH gene usage and accumulation of somatic mutations in D regions.Semantic proximity Read ↗

Altered phenotypic expression of immunoglobulin heavy-chain variable-region (VH) genes in Alicia rabbits probably reflects a small deletion in the VH genes closest to the joining region.Semantic proximity Read ↗

B-cell superantigens may play a role in B-cell development and selection in the young rabbit appendix.Semantic proximity Read ↗

Somatic diversification of immunoglobulin heavy chain VDJ genes: evidence for somatic gene conversion in rabbits.Semantic proximity Read ↗

Preferential expansion and survival of B lymphocytes based on VH framework 1 and framework 3 expression: "positive" selection in appendix of normal and VH-mutant rabbits.Semantic proximity Read ↗

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