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Article

Characterization of a rabbit germ-line VH gene that is a candidate donor for VH gene conversion in mutant Alicia rabbits.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 1995

Chen H T, Alexander C B, Mage R G

Abstract excerpt

Normal rabbits preferentially rearrange the 3'-most VH gene, VH1, to encode Igs with VHa allotypes, which constitute the majority of rabbit serum Igs. A gene conversion-like mechanism is employed to diversify the primary Ab repertoire. In mutant Alicia rabbits that derived from a rabbit with VHa2 allotype, the VH1 gene was deleted. Our previous studies showed that the first functional gene (VH4) or VH4-like genes...

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PMID: 7759874

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Characterization of a rabbit germ-line VH gene that is a candidate donor for VH gene conversion in mutant Alicia rabbits.PMID 7759874Read ↗

VH gene expression and regulation in the mutant Alicia rabbit. Rescue of VHa2 allotype expression.Semantic proximity Read ↗

VH mutant rabbits lacking the VH1a2 gene develop a2+ B cells in the appendix by gene conversion-like alteration of a rearranged VH4 gene.Semantic proximity Read ↗

Preferrential rearrangement in normal rabbits of the 3' VHa allotype gene that is deleted in Alicia mutants; somatic hypermutation/conversion may play a major role in generating the heterogeneity of rabbit heavy chain variable region sequences.Semantic proximity Read ↗

Limited number of immunoglobulin VH regions expressed in the mutant rabbit "Alicia".Semantic proximity Read ↗

Molecular basis of the allelic inheritance of rabbit immunoglobulin VH allotypes: implications for the generation of antibody diversity.Semantic proximity Read ↗

B lymphocyte selection and age-related changes in VH gene usage in mutant Alicia rabbits.Semantic proximity Read ↗

Diversification of rabbit VH genes by gene-conversion-like and hypermutation mechanisms.Semantic proximity Read ↗

VDJ genes in VHa2 allotype-suppressed rabbits. Limited germline VH gene usage and accumulation of somatic mutations in D regions.Semantic proximity Read ↗

Altered phenotypic expression of immunoglobulin heavy-chain variable-region (VH) genes in Alicia rabbits probably reflects a small deletion in the VH genes closest to the joining region.Semantic proximity Read ↗

B-cell superantigens may play a role in B-cell development and selection in the young rabbit appendix.Semantic proximity Read ↗

Somatic diversification of immunoglobulin heavy chain VDJ genes: evidence for somatic gene conversion in rabbits.Semantic proximity Read ↗

Preferential expansion and survival of B lymphocytes based on VH framework 1 and framework 3 expression: "positive" selection in appendix of normal and VH-mutant rabbits.Semantic proximity Read ↗

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