Article
VH mutant rabbits lacking the VH1a2 gene develop a2+ B cells in the appendix by gene conversion-like alteration of a rearranged VH4 gene.
Journal of immunology (Baltimore, Md. : 1950) - 1 Feb 1998
Sehgal D, Mage R G, Schiaffella E
Abstract excerpt
We investigated the molecular basis for the appearance of V(H)a2 allotype-bearing B cells in mutant Alicia rabbits. The mutation arose in an a2 rabbit; mutants exhibit altered expression of V(H) genes because of a small deletion encompassing V(H)1a2, the 3'-most gene in the V(H) locus. The V(H)1...
Topics
- Amino Acid Sequence
- Animals
- Antibody Diversity
- Appendix
- B-Lymphocytes
- Base Sequence
- Flow Cytometry
- Gene Conversion
- Gene Rearrangement, B-Lymphocyte, Heavy Chain
- Genes, Immunoglobulin
- Immunoglobulin Allotypes
- Immunoglobulin Heavy Chains
- Immunoglobulin M
- Immunoglobulin Variable Region
- Molecular Sequence Data
- Multigene Family
- Mutation
- Rabbits