Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Distinct clonal Ig diversification patterns in young appendix compared to antigen-specific splenic clones.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jun 2002

Sehgal Devinder, Obiakor Harold, Mage Rose G

Abstract excerpt

The young rabbit appendix is a dynamic site for primary B cell repertoire development. To study diversification patterns during clonal expansion, we collected single appendix B cells from 3- to 9-wk-old rabbits and sequenced rearranged H and L chain genes. Single cells obtained by hydraulic micromanipulation or laser capture microdissection were lysed, PCR amplified, and products directly sequenced. Gene...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens
Share to Complementarity Determining Regions

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Conversion

Share to Gene Rearrangement

Share to Genes, Immunoglobulin

Share to Immunoglobulin Variable Region

Share to Rabbits

Share to Spleen

Source

Identifiers

PMID: 12023335
DOI: 10.4049/jimmunol.168.11.5424

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Distinct clonal Ig diversification patterns in young appendix compared to antigen-specific splenic clones.PMID 12023335Read ↗

Gene-conversion in rabbit B-cell ontogeny and during immune responses in splenic germinal centers.Semantic proximity Read ↗

Development of the antibody repertoire in rabbit: gut-associated lymphoid tissue, microbes, and selection.Semantic proximity Read ↗

Rabbit IgH sequences in appendix germinal centers: VH diversification by gene conversion-like and hypermutation mechanisms.Semantic proximity Read ↗

Antigen-Induced Somatic Diversification of Rabbit IgH Genes: Gene Conversion and Point MutationSemantic proximity Read ↗

Generation of heterogeneous rabbit anti-DNP antibodies by gene conversion and hypermutation of rearranged VL and VH genes during clonal expansion of B cells in splenic germinal centers.Semantic proximity Read ↗

B-cell superantigens may play a role in B-cell development and selection in the young rabbit appendix.Semantic proximity Read ↗

Somatic diversification of immunoglobulin heavy chain VDJ genes: evidence for somatic gene conversion in rabbits.Semantic proximity Read ↗

Somatic hypermutation: mutations 3' of rabbit VDJ H-chain genes.Semantic proximity Read ↗

Gene conversion and hypermutation during diversification of VH sequences in developing splenic germinal centers of immunized rabbits.Semantic proximity Read ↗

Diversification of rabbit VH genes by gene-conversion-like and hypermutation mechanisms.Semantic proximity Read ↗

Systematic Characterization and Comparative Analysis of the Rabbit Immunoglobulin RepertoireSemantic proximity Read ↗

Antibody diversification in the rabbit: historical and contemporary perspectives.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.