Diversification of rabbit VH genes by gene-conversion-like and hypermutation mechanisms.

doi:10.1111/j.1600-065x.1998.tb01428.x

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Article

Diversification of rabbit VH genes by gene-conversion-like and hypermutation mechanisms.

Immunological reviews - 1 Apr 1998

Mage R G

Abstract excerpt

Where, when and how does VH diversification occur in the rabbit? Early diversification by gene-conversion and somatic hypermutation in rabbit appendix and chicken bursa of Fabricius are similar processes; the chicken bursa and the rabbit appendix have homologous functions. However, diversificatio...

Topics

Animals
Antibody Diversity
B-Lymphocytes
Gene Conversion
Humans
Immunoglobulin Heavy Chains
Immunoglobulin Variable Region
Intestines
Lymphoid Tissue
Mutation
Rabbits

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