Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Development of the antibody repertoire in rabbit: gut-associated lymphoid tissue, microbes, and selection.

Immunological reviews - 1 Jun 2000

Lanning D, Zhu X, Zhai S K, Knight K L

Abstract excerpt

Rabbits generate their antibody repertoire in three stages. First, a neonatal repertoire is generated by B lymphopoiesis in fetal liver and bone marrow and is limited by preferential V(H) gene segment usage. Between 4 and 8 weeks after birth a complex primary antibody repertoire is developed by somatically diversifying the neonatal repertoire through somatic hypermutation and a somatic gene conversion-like...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibody Diversity
Share to Gene Conversion
Share to Gene Rearrangement, B-Lymphocyte

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, Immunoglobulin

Share to Immunoglobulin Variable Region

Share to Intestines

Share to Lymphoid Tissue

Share to Models, Immunological

Source

Identifiers

PMID: 10933605

Genes

GALT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Development of the antibody repertoire in rabbit: gut-associated lymphoid tissue, microbes, and selection.PMID 10933605Read ↗

Development of the antibody repertoire in rabbits.Semantic proximity Read ↗

B-cell superantigens may play a role in B-cell development and selection in the young rabbit appendix.Semantic proximity Read ↗

Antibody diversification in the rabbit: historical and contemporary perspectives.Semantic proximity Read ↗

Gene-conversion in rabbit B-cell ontogeny and during immune responses in splenic germinal centers.Semantic proximity Read ↗

Diversification of the Primary Antibody Repertoire by AID-Mediated Gene Conversion.Semantic proximity Read ↗

Somatic diversification of immunoglobulin heavy chain VDJ genes: evidence for somatic gene conversion in rabbits.Semantic proximity Read ↗

Rabbit IgH sequences in appendix germinal centers: VH diversification by gene conversion-like and hypermutation mechanisms.Semantic proximity Read ↗

Systematic Characterization and Comparative Analysis of the Rabbit Immunoglobulin RepertoireSemantic proximity Read ↗

Distinct clonal Ig diversification patterns in young appendix compared to antigen-specific splenic clones.Semantic proximity Read ↗

The functional repertoire of rabbit antibodies and antibody discovery via next-generation sequencing.Semantic proximity Read ↗

Diversification of rabbit VH genes by gene-conversion-like and hypermutation mechanisms.Semantic proximity Read ↗

Generation of heterogeneous rabbit anti-DNP antibodies by gene conversion and hypermutation of rearranged VL and VH genes during clonal expansion of B cells in splenic germinal centers.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.