Article
Molecular bases of genetic diversity and evolution of the immunoglobulin heavy chain variable region (IGHV) gene locus in leporids.
Immunogenetics - 1 Jul 2011
Pinheiro Ana, Lanning Dennis, Alves Paulo C, Mage Rose G, Knight Katherine L, van der Loo Wessel, Esteves Pedro J
Abstract excerpt
The rabbit has long been a model for studies of the immune system. Work using rabbits contributed both to the battle against infectious diseases such as rabies and syphilis, and to our knowledge, of antibodies' structure, function, and regulated expression. With the description of rabbit Ig allotypes, the discovery of different gene segments encoding immunoglobulins became possible. This challenged the "one...
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