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Article

Somatic hypermutation: mutations 3' of rabbit VDJ H-chain genes.

Journal of immunology (Baltimore, Md. : 1950) - 1 Nov 1997

Lanning D K, Knight K L

Abstract excerpt

VDJ genes of rabbit B cells are diversified by a somatic gene conversion-like mechanism in which V(H) gene segments 5' of the VDJ gene serve as donors. To assess whether somatic mutation also contributes to Ab diversification in the rabbit, we searched for mutations 3' of VDJ genes because mutations in this region presumably result from somatic mutation rather than gene conversion. We PCR-amplified and cloned the...

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PMID: 9379038

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