Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Gene-conversion in rabbit B-cell ontogeny and during immune responses in splenic germinal centers.

Veterinary immunology and immunopathology - 15 Dec 1999

Mage R G, Sehgal D, Schiaffella E, Anderson A O

Abstract excerpt

Combinatorial diversity is limited in rabbits because only a few V(H) genes rearrange. Most diversification of the primary repertoire is generated by somatic hypermutation and gene conversion-like changes of rearranged V(H) in B cells that migrate to appendix and other gut associated lymphoid tissues (GALT) of young rabbits. The changes are referred to as gene conversion-like because the non-reciprocal nature of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibody Diversity
Share to B-Lymphocytes
Share to Gene Conversion

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, Immunoglobulin

Share to Genetic Variation

Share to Germinal Center

Share to Rabbits

Share to Spleen

Source

Identifiers

PMID: 10614487
DOI: 10.1016/s0165-2427(99)00110-5

Genes

GALT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gene-conversion in rabbit B-cell ontogeny and during immune responses in splenic germinal centers.PMID 10614487Read ↗

Gene conversion and hypermutation during diversification of VH sequences in developing splenic germinal centers of immunized rabbits.Semantic proximity Read ↗

Rabbit IgH sequences in appendix germinal centers: VH diversification by gene conversion-like and hypermutation mechanisms.Semantic proximity Read ↗

Development of the antibody repertoire in rabbit: gut-associated lymphoid tissue, microbes, and selection.Semantic proximity Read ↗

Generation of heterogeneous rabbit anti-DNP antibodies by gene conversion and hypermutation of rearranged VL and VH genes during clonal expansion of B cells in splenic germinal centers.Semantic proximity Read ↗

Distinct clonal Ig diversification patterns in young appendix compared to antigen-specific splenic clones.Semantic proximity Read ↗

Diversification of rabbit VH genes by gene-conversion-like and hypermutation mechanisms.Semantic proximity Read ↗

Somatic hypermutation: mutations 3' of rabbit VDJ H-chain genes.Semantic proximity Read ↗

Antigen-Induced Somatic Diversification of Rabbit IgH Genes: Gene Conversion and Point MutationSemantic proximity Read ↗

Somatic diversification of immunoglobulin heavy chain VDJ genes: evidence for somatic gene conversion in rabbits.Semantic proximity Read ↗

Systematic Characterization and Comparative Analysis of the Rabbit Immunoglobulin RepertoireSemantic proximity Read ↗

Immunoglobulin gene conversion identification and analysisSemantic proximity Read ↗

B-cell superantigens may play a role in B-cell development and selection in the young rabbit appendix.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.