Neocarzinostatin-induced mutations at the hprt locus in exponentially growing CHO cells, compared with spontaneous mutations.

doi:10.1093/carcin/19.5.791

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Article

Neocarzinostatin-induced mutations at the hprt locus in exponentially growing CHO cells, compared with spontaneous mutations.

Carcinogenesis - 1 May 1998

Kimura H, Takada T, Shingu Y, Kato Y, Iyehara-Ogawa H, Terado T

Abstract excerpt

Spontaneous mutations and neocarzinostatin-induced mutations were investigated in the hypoxanthine-guanine phosphoribosyltransferase (hprt) gene in exponentially growing Chinese hamster ovary cells. Neocarzinostatin (NCS) treatment caused an 4.5-fold increase in mutation frequency. Analysis by mu...

Topics

Animals
Antibiotics, Antineoplastic
CHO Cells
Cricetinae
Hypoxanthine Phosphoribosyltransferase
Mutation
Polymerase Chain Reaction
RNA Splicing
Sequence Deletion
Zinostatin

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