Frequency of HPRT gene mutations induced by N-methyl-N'-nitro-N-nitrosoguanidine corresponds to replication error phenotypes of cell lines.

doi:10.1016/s0027-5107(97)00244-3

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Article

Frequency of HPRT gene mutations induced by N-methyl-N'-nitro-N-nitrosoguanidine corresponds to replication error phenotypes of cell lines.

Mutation research - 26 Feb 1998

Zhu W, Yamasaki H, Mironov N

Abstract excerpt

We have examined whether cells with replication error-positive (RER+) and -negative phenotype (RER ) respond differently to the mutagen MNNG, employing three RER+ and two RER- human cell lines. Cells were treated with several concentrations of MNNG, and HPRT mutants were selected phenotypically b...

Topics

Cell Line
DNA Replication
Humans
Hypoxanthine Phosphoribosyltransferase
Methylnitronitrosoguanidine
Mutagens
Mutation
Phenotype

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