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Article

Spectrum of spontaneously occurring mutations in the hprt gene of V79 Chinese hamster cells.

Journal of molecular biology - 5 Feb 1992

Zhang L H, Vrieling H, van Zeeland A A, Jenssen D

Abstract excerpt

A total of 76 independent spontaneous mutants in the hprt gene of V79 Chinese hamster cells have been analyzed. These mutants were obtained in two different laboratories, 17 and 59 mutants in sets 1 and 2, respectively, under different cell culture conditions. Mutation analysis was performed by amplification of hprt cDNA with the polymerase chain reaction and direct sequencing of the products. The data obtained...

Topics

Animals
Base Sequence
Blotting, Southern
Cell Line
Chromosome Deletion
Cricetinae
Cricetulus
DNA
DNA Mutational Analysis
Frameshift Mutation
Hypoxanthine Phosphoribosyltransferase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Multigene Family

Mutation

Polymerase Chain Reaction

RNA Splicing

Source

Identifiers

PMID: 1542110
DOI: 10.1016/0022-2836(92)90979-t

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1542110-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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