Spectrum of spontaneously occurring mutations in the HPRT gene of the Chinese hamster V79 cell mutant V-H4, which is homologous to Fanconi anemia group A.

doi:10.1093/mutage/11.2.155

Article

Spectrum of spontaneously occurring mutations in the HPRT gene of the Chinese hamster V79 cell mutant V-H4, which is homologous to Fanconi anemia group A.

Mutagenesis - 1 Mar 1996

Telleman P, Overkamp W J, Zdzienicka M Z

Abstract excerpt

The mitomycin C (MMC)-hypersensitive Chinese hamster V79 cell mutant V-H4 has a cellular phenotype similar to Fanconi anemia (FA), and has been shown to be homologous to FA group A. To examine consequences of the defect in V-H4 cells on spontaneous mutagenesis, we studied the frequency and nature...

Topics

Animals
Base Sequence
Cell Line
Cricetinae
Cricetulus
DNA
DNA Mutational Analysis
Fanconi Anemia
Hypoxanthine Phosphoribosyltransferase
Molecular Sequence Data
Mutation
Polymerase Chain Reaction
RNA Splicing

Spectrum of spontaneously occurring mutations in the HPRT gene of the Chinese hamster V79 cell mutant V-H4, which is homologous to Fanconi anemia group A.

Abstract excerpt

Topics

Discuss the evidence