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Article

Expression of the endogenous O6-methylguanine-DNA-methyltransferase protects Chinese hamster ovary cells from spontaneous G:C to A:T transitions.

Cancer research - 1 Dec 1992

Aquilina G, Biondo R, Dogliotti E, Meuth M, Bignami M

Abstract excerpt

We have investigated whether the presence of a DNA repair enzyme, O6-methylguanine-DNA-methyltransferase (MGMT), affects the nature of spontaneous mutations in a mammalian cell line. We compared spontaneous mutations in the adenine phosphoribosyl transferase gene of a Chinese hamster ovary (CHO) cell line that expressed 14,000 MGMT molecules/cell with those in the parental CHO cells lacking this DNA repair...

Topics

Adenine Phosphoribosyltransferase
Amino Acid Sequence
Animals
Base Sequence
Blotting, Southern
CHO Cells
Cricetinae
Exons
Frameshift Mutation
Guanine
Methyltransferases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

O(6)-Methylguanine-DNA Methyltransferase

Source

Identifiers

PMID: 1423294

Genes

MGMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1423294-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Expression of the endogenous O6-methylguanine-DNA-methyltransferase protects Chinese hamster ovary cells from spontaneous G:C to A:T transitions.PMID 1423294Read ↗

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