Spectrum of spontaneous mutation in animal cells containing an aphidicolin-resistant DNA polymerase alpha.

doi:10.1016/0027-5107(93)90089-x

Back to search

Article

Spectrum of spontaneous mutation in animal cells containing an aphidicolin-resistant DNA polymerase alpha.

Mutation research - 1 Aug 1993

Liu P K, Trujillo J M, Monnat R J

Abstract excerpt

We have used a polymerase chain reaction (PCR)-based exon screening assay to determine the spectrum of spontaneous hypoxanthine phosphoribosyltransferase (hprt) gene mutations occurring in an aphidicolin-resistant V79 Chinese hamster cell line (designated Aphr-4-2) that contains a mutant DNA poly...

Topics

Animals
Aphidicolin
Base Sequence
Cell Line
Cricetinae
DNA
DNA Polymerase II
Drug Resistance
Hypoxanthine Phosphoribosyltransferase
Molecular Sequence Data
Mutation

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.