Article
Gene rearrangements induced by the DNA double-strand cleaving agent neocarzinostatin: conservative non-homologous reciprocal exchanges in an otherwise stable genome.
Nucleic acids research - 15 Jun 2002
Wang Peng, Lee Jae Wan, Yu Yin, Turner Kristi, Zou Ying, Jackson-Cook Colleen K, Povirk Lawrence F
Abstract excerpt
Among a collection of 74 aprt mutations induced by treatment of plateau phase Chinese hamster ovary CHO cells with the radiomimetic DNA double-strand cleaving agent neocarzinostatin, nine were large-scale rearrangements. Molecular analysis indicated that all nine were highly conservative, non-homologous reciprocal exchanges, most of which were intrachromosomal as determined by fluorescence in situ hybridization....
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