Article
Strand- and sequence-specific attenuation of N-methyl-N'-nitro-N-nitrosoguanidine-induced G.C to A.T transitions by expression of human 6-methylguanine-DNA methyltransferase in Chinese hamster ovary cells.
Cancer research - 15 Jul 1994
Yang J L, Hsieh F P, Lee P C, Tseng H J
Abstract excerpt
The effect of human O6-methylguanine-DNA methyltransferase (MGMT) on the cytotoxicity, the mutagenicity, and the specific kinds of base substitutions induced by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) were examined in non-MGMT transfected Chinese hamster ovary cells (CHOM cells) and in those...
Topics
- Animals
- Base Sequence
- CHO Cells
- Cell Survival
- Cricetinae
- Dose-Response Relationship, Drug
- Humans
- Hypoxanthine Phosphoribosyltransferase
- Methylnitronitrosoguanidine
- Methyltransferases
- Molecular Sequence Data
- Mutation
- O(6)-Methylguanine-DNA Methyltransferase