High frequency of p53 protein accumulation without p53 gene mutation in human juvenile pilocytic, low grade and anaplastic astrocytomas.

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Article

High frequency of p53 protein accumulation without p53 gene mutation in human juvenile pilocytic, low grade and anaplastic astrocytomas.

Oncogene - 1 Mar 1994

Lang F F, Miller D C, Pisharody S, Koslow M, Newcomb E W

Abstract excerpt

We analysed 31 non-glioblastoma astrocytomas for alterations in p53 protein expression and for mutations in the p53 gene. Immunohistochemistry detected p53 protein accumulation in 71% (five of seven) of juvenile pilocytic astrocytomas (WHO grade I), 63% (five of eight) of astrocytomas (WHO grade...

Topics

Adolescent
Adult
Aged
Astrocytoma
Base Sequence
Brain Neoplasms
Child
Child, Preschool
DNA, Neoplasm
Female
Genes, p53
Glioblastoma
Humans
Male
Middle Aged
Molecular Sequence Data
Mutation
Tumor Suppressor Protein p53

Source

Open in PubMed

Identifiers

PMID: 8108140

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8108140-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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