Article
High frequency of TP53 mutations in juvenile pilocytic astrocytomas indicates role of TP53 in the development of these tumors.
Brain pathology (Zurich, Switzerland) - 1 Jul 1999
Hayes V M, Dirven C M, Dam A, Verlind E, Molenaar W M, Mooij J J, Hofstra R M, Buys C H
Abstract excerpt
In adults, the TP53 tumor suppressor gene is frequently mutated in astrocytic brain tumors which is supposed to represent an early event in their development. In juvenile pilocytic and low-grade astrocytomas, however, TP53 mutations have until now been reported as rare, which has led to the suggestion that these tumors may follow a different molecular pathogenesis with an involvement of genes other than TP53. Our...
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