Article
p53 mutation and protein alteration in 50 gliomas. Retrospective study by DNA-sequencing techniques and immunohistochemistry.
Histology and histopathology - 1 Jul 1997
von Eckardstein K, Gries H, Bolik E, Cervós-Navarro J, Tschairkin I N, Patt S
Abstract excerpt
Alterations of the p53 protein, which is a 53 kD phosphoprotein and gene product of the p53 gene, has been found to play a major role in the genesis of a variety of human malignancies including tumors of the central nervous system. We investigated 50 tumor specimens from primary central nervous s...
Topics
- Central Nervous System Neoplasms
- DNA
- Genes, p53
- Glioma
- Humans
- Immunohistochemistry
- Mutation
- Polymorphism, Single-Stranded Conformational
- Retrospective Studies
- Sequence Analysis
- Tumor Suppressor Protein p53