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Article

Molecular genetic analysis of p53 intratumoral heterogeneity in human astrocytic brain tumors.

Journal of neuropathology and experimental neurology - 1 Oct 2007

Ren Zhi-Ping, Olofsson Tommie, Qu Mingqi, Hesselager Göran, Soussi Thierry, Kalimo Hannu, Smits Anja, Nistér Monica

Abstract excerpt

We investigated genetic heterogeneity of astrocytic gliomas using p53 gene mutations as a marker. Different parts of morphologically heterogeneous astrocytic gliomas were microdissected, and direct DNA sequencing of p53 gene exons 5 through 8 was performed. Thirty-five glioma samples and tumor-adjacent normal-appearing brain tissue from 11 patients were analyzed. Sixteen different p53 gene mutations were found in...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 17917588
DOI: 10.1097/nen.0b013e318156bc05

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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