Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutational and expression analysis of the NF1 gene argues against a role as tumor suppressor in sporadic pilocytic astrocytomas.

Journal of neuropathology and experimental neurology - 1 Oct 2002

Wimmer Katharina, Eckart Markus, Meyer-Puttlitz Birgit, Fonatsch Christa, Pietsch Torsten

Abstract excerpt

Children with neurofibromatosis type I (NF1) have a highly increased risk for developing optic nerve gliomas. Several lines of evidence support the notion that the NF1 gene functions as tumor suppressor in these pilocytic astrocytomas and therefore it is tempting to hypothesize that the NF1 gene plays a similar role in sporadic pilocytic astrocytomas. We searched for possible mechanisms of inactivation of the NF1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Astrocytoma
Share to Brain Neoplasms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, Neurofibromatosis 1

Share to Genes, Tumor Suppressor

Share to Loss of Heterozygosity

Share to Neurofibromin 1

Share to Plasmids

Share to Recombinant Proteins

Source

Identifiers

PMID: 12387455
DOI: 10.1093/jnen/61.10.896

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutational and expression analysis of the NF1 gene argues against a role as tumor suppressor in sporadic pilocytic astrocytomas.PMID 12387455Read ↗

Loss of neurofibromatosis 1 (<i>NF1</i>) gene expression in NF1‐associated pilocytic astrocytomasSemantic proximity Read ↗

Loss of NF1 alleles distinguish sporadic from NF1-associated pilocytic astrocytomas.Semantic proximity Read ↗

Somatic neurofibromatosis type 1 (NF1) inactivation characterizes NF1-associated pilocytic astrocytoma.Semantic proximity Read ↗

Cancer-related gene expression profiles in NF1-associated pilocytic astrocytomasSemantic proximity Read ↗

Genetic characterization of an aggressive optic nerve pilocytic glioma.Semantic proximity Read ↗

Neurofibromatosis type 1 associated low grade gliomas: A comparison with sporadic low grade gliomas.Semantic proximity Read ↗

Gene Expression Profiling of NF-1-Associated and Sporadic Pilocytic Astrocytoma Identifies Aldehyde Dehydrogenase 1 Family Member L1 (ALDH1L1) as an Underexpressed Candidate Biomarker in Aggressive SubtypesSemantic proximity Read ↗

Astrocyte-Specific Inactivation of the Neurofibromatosis 1 Gene (<i>NF1</i>) Is Insufficient for Astrocytoma FormationSemantic proximity Read ↗

Germline and somatic NF1 gene mutations in plexiform neurofibromas.Semantic proximity Read ↗

Absence of p53 gene mutations in a tumor panel representative of pilocytic astrocytoma diversity using a p53 functional assay.Semantic proximity Read ↗

Null phenotype of neurofibromatosis type 1 in a carrier of a heterozygous atypical NF1 deletion due to mosaicism.Semantic proximity Read ↗

Somatic NF1 mutational spectrum in benign neurofibromas: mRNA splice defects are common among point mutations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.