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Article

Somatic hypermutation of the T cell receptor V beta gene in microdissected splenic white pulps from HIV-1-positive patients.

European journal of immunology - 1 May 1998

Cheynier R, Henrichwark S, Wain-Hobson S

Abstract excerpt

Somatic mutation of rearranged immunoglobulin V genes occurs in germinal centers (GC), resulting in affinity maturation of the immune response. Rearranged T cell receptor (TCR) genes were thought to be excluded from this process despite similarities in their gene structure. Somatic mutations were found among TCR V alpha (TCRAV) chains of antigen-specific T cells localized in GC of mice. Here, somatically mutated...

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Source

Identifiers

PMID: 9603466
DOI: 10.1002/(SICI)1521-4141(199805)28:05<1604::AID-IMMU1604>3.0.CO;2-R

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Somatic hypermutation of the T cell receptor V beta gene in microdissected splenic white pulps from HIV-1-positive patients.PMID 9603466Read ↗

Analysis of mutations in immunoglobulin heavy chain variable region genes of microdissected marginal zone (MGZ) B cells suggests that the MGZ of human spleen is a reservoir of memory B cells.Semantic proximity Read ↗

Locus-specific somatic hypermutation in germinal centre T cells.Semantic proximity Read ↗

Highly restricted spread of HIV-1 and multiply infected cells within splenic germinal centersSemantic proximity Read ↗

Clonal expansion of T cells and HIV genotypes in microdissected splenic white pulps indicates viral replication in situ and infiltration of HIV-specific cytotoxic T lymphocytes.Semantic proximity Read ↗

Somatic hypermutation introduces insertions and deletions into immunoglobulin V genes.Semantic proximity Read ↗

The signature of somatic hypermutation appears to be written into the germline IgV segment repertoire.Semantic proximity Read ↗

Boundaries of somatic mutation in rearranged immunoglobulin genes: 5' boundary is near the promoter, and 3' boundary is approximately 1 kb from V(D)J gene.Semantic proximity Read ↗

Analysis of the T-cell receptor beta-chain variable-region (V beta) repertoire in monozygotic twins discordant for human immunodeficiency virus: evidence for perturbations of specific V beta segments in CD4+ T cells of the virus-positive twins.Semantic proximity Read ↗

Analysis of individual immunoglobulin lambda light chain genes amplified from single cells is inconsistent with variable region gene conversion in germinal-center B cell somatic mutation.Semantic proximity Read ↗

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In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. III. The kinetics of V region mutation and selection in germinal center B cells.Semantic proximity Read ↗

Targeting and selection of mutations in human Vlambda rearrangements.Semantic proximity Read ↗

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