Article
Somatic hypermutation of the T cell receptor V beta gene in microdissected splenic white pulps from HIV-1-positive patients.
European journal of immunology - 1 May 1998
Cheynier R, Henrichwark S, Wain-Hobson S
Abstract excerpt
Somatic mutation of rearranged immunoglobulin V genes occurs in germinal centers (GC), resulting in affinity maturation of the immune response. Rearranged T cell receptor (TCR) genes were thought to be excluded from this process despite similarities in their gene structure. Somatic mutations were...
Topics
- Base Sequence
- Cell Line
- Dissection
- Gene Rearrangement, beta-Chain T-Cell Antigen Receptor
- Germinal Center
- HIV Seropositivity
- Humans
- Molecular Sequence Data
- Mutation
- Receptor-CD3 Complex, Antigen, T-Cell
- Receptors, Antigen, T-Cell, alpha-beta
- Spleen
- Splenectomy
- T-Lymphocytes, Cytotoxic