Analysis of mutations in immunoglobulin heavy chain variable region genes of microdissected marginal zone (MGZ) B cells suggests that the MGZ of human spleen is a reservoir of memory B cells.

Abstract excerpt

The splenic marginal zone (MGZ), which surrounds the mantle zone (MTZ) in human splenic white pulp, contains a phenotypically and morphologically distinct population of B cells. The origin of MGZ B cells is uncertain. Whereas some experiments in rodents have suggested that they are a distinct cell lineage responsible for the immune response to T-independent type 2 antigens, others have suggested that they are...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Galectins and Cancer Biology
• Share to Monoclonal and Polyclonal Antibodies Research
• Share to T-cell and B-cell Immunology