Article
Analysis of individual immunoglobulin lambda light chain genes amplified from single cells is inconsistent with variable region gene conversion in germinal-center B cell somatic mutation.
European journal of immunology - 1 Aug 1994
Ford J E, McHeyzer-Williams M G, Lieber M R
Abstract excerpt
Responding B cells in specific immune responses diversify their immunoglobulin genes and are selected on their variant antigen receptors in the microenvironment of the germinal center. The patterns of mutations previously reported for immunglobulin (Ig) genes have supported mechanistic hypotheses...
Topics
- Amino Acid Sequence
- Animals
- B-Lymphocytes
- Base Sequence
- Flow Cytometry
- Gene Rearrangement, B-Lymphocyte
- Immunoglobulin Variable Region
- Immunoglobulin lambda-Chains
- Lymph Nodes
- Mice
- Mice, Inbred C57BL
- Molecular Sequence Data
- Mutation