Article
Somatic hypermutation introduces insertions and deletions into immunoglobulin V genes.
The Journal of experimental medicine - 5 Jan 1998
Wilson P C, de Bouteiller O, Liu Y J, Potter K, Banchereau J, Capra J D, Pascual V
Abstract excerpt
During a germinal center reaction, random mutations are introduced into immunoglobulin V genes to increase the affinity of antibody molecules and to further diversify the B cell repertoire. Antigen-directed selection of B cell clones that generate high affinity surface Ig results in the affinity...
Topics
- Amino Acid Sequence
- B-Lymphocytes
- Base Sequence
- DNA, Complementary
- Genes, Immunoglobulin
- Humans
- Immunoglobulin Heavy Chains
- Immunoglobulin Variable Region
- In Vitro Techniques
- Models, Genetic
- Molecular Sequence Data
- Mutation
- Recombination, Genetic
- Sequence Deletion
- Sequence Homology, Nucleic Acid